Structure of PDB 7amv Chain W

Receptor sequence

>7amvW (length=637) Species: 502057 (Vaccinia virus GLV-1h68)

MNTGIIDLFDNHVDSIPTILPHQLATLDYLVRTIIDENRSVLLFHIMGSG
KTIIALLFALVASRFKKVYILVPNINILKIFNYNMGVAMNLFNDEFIAEN
IFIHSTTSFYSLNYNDNVINYNGLSRYNNSIFIVDEAHNIFGNNTGELMT
VIKNKNKIPFLLLSGSPITNTPNTLGHIIDLMSEETIDFGEIISRGKKVI
QTLLNERGVNVLKDLLKGRISYYEMPDKDLPTIRYHGRKFLDTRVVYCHM
SKLQERDYMITRRQLCYHEMFDKNMYNVSMAVLGQLNLMNNLDTLFQEQD
KELYPNLKINNGVLYGEELVTLNISSKFKYFINRIQTLNGKHFIYFSNST
YGGLVIKYIMLSNGYSEYNGSQGTNPHMINGKPKTFAIVTSKMKSSLEDL
LDVYNSPENDDGSQLMFLFSSNIMSESYTLKEVRHIWFMTIPDTFSQYNQ
ILGRSIRKFSYADISEPVNVYLLAAVYSDFNDEVTSLNDYTQDELINVLP
FDIKKLLYLKFKTKETNRIYSILQEMSETYSLPPHPSIVKVLLGELVRQF
FYNNSRIKYNDTKLLKMVTSVIKNKEDARNYIDDIVNGHFFVSNKVFDKS
LLYKYENDIITVPFRLSYEPFVWGVNFRKEYNVVSSP

3D structure

• PDB: 7amv Structural basis of the complete poxvirus transcription initiation process.
• Chain: W
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	W	N143 N144 N170 K197 V199 H268 F271 D443 K512	N143 N144 N170 K197 V199 H268 F271 D443 K512
BS02	dna	W	N74 I75 S105 T107 E191 R195 Y267 F271 K273 N290 L292 S349 T350 S391 S421 I423 M424	N74 I75 S105 T107 E191 R195 Y267 F271 K273 N290 L292 S349 T350 S391 S421 I423 M424

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds

Cellular Component

• GO:0016020 membrane
• GO:0044423 virion component

External links

• PDB: RCSB:7amv, PDBe:7amv, PDBj:7amv
• PDBsum: 7amv
• PubMed: 34556871
• UniProt: Q49QE8