Structure of PDB 6y69 Chain W

Receptor sequence

>6y69W (length=75) Species: 83333 (Escherichia coli K-12)

RNGRDSEAKRLGVKRFGGESVLAGSIIVRQRGTKFHAGANVGCGRDHTLF
AKADGKVKFEVKGPKNRKFISIEAE

3D structure

• PDB: 6y69 Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel.
• Chain: W
• Resolution: 2.86 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	W	R7 N8 R10 D11 S12 E13 A14 K15 R16 K20 R21 F22 G23 E25 L28 A29 G30 S31 I32 R37 G38 T39 K40 F41 H42 G50 R51 D52 T54 F56 F65 K71 R73 K74	R1 N2 R4 D5 S6 E7 A8 K9 R10 K14 R15 F16 G17 E19 L22 A23 G24 S25 I26 R31 G32 T33 K34 F35 H36 G44 R45 D46 T48 F50 F59 K65 R67 K68
BS02	rna	W	G69 P70 N72	G63 P64 N66

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6y69, PDBe:6y69, PDBj:6y69
• PDBsum: 6y69
• PubMed: 32601485
• UniProt: P0A7L8|RL27_ECOLI Large ribosomal subunit protein bL27 (Gene Name=rpmA)