Structure of PDB 6wnk Chain W

Receptor sequence
>6wnkW (length=223) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
TTIVALKYPGGVVMAGDRRSTQGNMISGRDVRKVYITDDYTATGIAGTAA
VAVEFARLYAVELEHYEKLEGVPLTFAGKINRLAIMVRGNLAAAMQGLLA
LPLLAGYDIHASDPQSAGRIVSFDAAGGWNIEEEGYQAVGSGSLFAKSSM
KKLYSQVTDGDSGLRVAVEALYDAADDDSATGGPDLVRGIFPTAVIIDAD
GAVDVPESRIAELARAIIESRSG
3D structure
PDB6wnk Macrocyclic Peptides that Selectively Inhibit the Mycobacterium tuberculosis Proteasome.
ChainW
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5Y W S122 F123 D124 W129 N130 S122 F123 D124 W129 N130
BS02 U5Y W S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 A52 S20 T21 Q22 S27 V31 K33 I45 G47 T48 A49 A52
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6wnk, PDBe:6wnk, PDBj:6wnk
PDBsum6wnk
PubMed33949190
UniProtP9WHT9|PSB_MYCTU Proteasome subunit beta (Gene Name=prcB)

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