Structure of PDB 6ryr Chain W

Receptor sequence

>6ryrW (length=708) Species: 9606 (Homo sapiens)

DHHMEFCRVCKDGGELLCCDTCPSSYHIHCLNPPLPEIPNGEWLCPRCTC
PALKGKVQKILIWKWGPERQFFVKWQGMSYWHCSWVSELQLELHCQVMFR
NYQRKNDMDEPPSEEKSRKRKNKDPKFAEMEERFYRYGIKPEWMMIHRIL
NHSVDKKGHVHYLIKWRDLPYDQASWESEDVEIQDYDLFKQSYWNHRELM
TVDPTVKYERQPEYLDATGGTLHPYQMEGLNWLRFSWAQGTDTILADEMG
LGKTVQTAVFLYSLYKEGHSKGPFLVSAPLSTIINWEREFEMWAPDMYVV
TYVGDKDSRAIIRENEFSFEDNAIRGGKKASRMKKEASVKFHVLLTSYEL
ITIDMAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGYSLQHKLLLTGTP
LQNNLEELFHLLNFLTPERFHNLEGFLEEFADIAKEDQIKKLHDMLGPHM
LRRLKADVFKNMPSKTELIVRVELSPMQKKYYKYILTRNFEALNARGGGN
QVSLLNVVMDLKKCCNHPYLFPVAAMEAPKMPNGMYDGSALIRASGKLLL
LQKMLKNLKEGGHRVLIFSQMTKMLDLLEDFLEHEGYKYERIDGGITGNM
RQEAIDRFNAPGAQQFCFLLSTRAGGLGINLATADTVIIYDSDWNPHNDI
QAFSRAHRIGQNKKVMIYRFVTRASVEERITQVAKKKMMLTHLVVRAAAA
AAAAAAAA

3D structure

• PDB: 6ryr Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations.
• Chain: W
• Resolution: 3.1 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	W	R572 R576 R813 K833 E853 I857 M1075 T1076 G1098 R1105 S1125 R1127 A1128	R100 R104 R309 K329 E349 I353 M571 T572 G594 R601 S621 R623 A624
BS02	dna	W	M570 R836 R877 K879 S883 K884 W1148 R1183 K1191	M98 R332 R373 K375 S379 K380 W644 R679 K687
BS03	ANP	W	Q730 M753 G754 L755 K757 T758 E793 R1159 R1162 I1163	Q226 M249 G250 L251 K253 T254 E289 R655 R658 I659
BS04	ZN	W	C452 H472 C475	C7 H27 C30
BS05	ZN	W	C464 S469 C490	C19 S24 C45

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0140658 ATP-dependent chromatin remodeler activity

Biological Process

• GO:0006338 chromatin remodeling

External links

• PDB: RCSB:6ryr, PDBe:6ryr, PDBj:6ryr
• PDBsum: 6ryr
• PubMed: 32543371
• UniProt: Q14839|CHD4_HUMAN Chromodomain-helicase-DNA-binding protein 4 (Gene Name=CHD4)