Structure of PDB 6ne3 Chain W

Receptor sequence

>6ne3W (length=461) Species: 9606 (Homo sapiens)

TRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQT
ISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKE
QRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKN
EKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFNSADDF
DSWFQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQREW
YTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYT
TDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRN
YEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADV
VILYDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEM
KLRLDSIVIQQ

3D structure

• PDB: 6ne3 Cryo-EM structures of remodeler-nucleosome intermediates suggest allosteric control through the nucleosome.
• Chain: W
• Resolution: 3.9 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	W	K238 K264 R267 E288 M289 K443 L447 N448 M451 Q507 M508 T509 D530 G531 S558 R560 A561	K73 K99 R102 E123 M124 K270 L274 N275 M278 Q334 M335 T336 D357 G358 S385 R387 A388
BS02	dna	W	K294 K298 K299 K314 S318 K319 L447 L450 R620	K129 K133 K134 K149 S153 K154 L274 L277 R447
BS03	ADP	W	K179 L180 Q184 G208 G210 K211 T212 E247 W251 R595 I596	K14 L15 Q19 G43 G45 K46 T47 E82 W86 R422 I423

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0140658 ATP-dependent chromatin remodeler activity

External links

• PDB: RCSB:6ne3, PDBe:6ne3, PDBj:6ne3
• PDBsum: 6ne3
• PubMed: 31210637
• UniProt: O60264|SMCA5_HUMAN SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (Gene Name=SMARCA5)