Structure of PDB 5cc1 Chain W

Receptor sequence
>5cc1W (length=75) Species: 9606 (Homo sapiens) [Search protein sequence]
PPKLCLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIID
KIRRKNCPACRYRKCLQAGMNLEAR
3D structure
PDB5cc1 Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
ChainW
Resolution2.302 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna W S440 F444 R447 R470 K471 R477 S24 F28 R31 R54 K55 R61 PDBbind-CN: Kd=0.085uM
BS02 dna W C431 H432 Y433 K442 K446 C15 H16 Y17 K26 K30 PDBbind-CN: Kd=0.085uM
BS03 ZN W C421 C424 C438 C441 C5 C8 C22 C25
BS04 ZN W C457 C463 C473 C476 C41 C47 C57 C60
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5cc1, PDBe:5cc1, PDBj:5cc1
PDBsum5cc1
PubMed26715749
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

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