Structure of PDB 6x89 Chain V1

Receptor sequence

>6x89V1 (length=433) Species: 157791 (Vigna radiata)

HFGGLKDEDRIFTNLYGLHDPFLKGAMKRGDWYRTKDLVIKGTDWIVNEM
KKSGLRGRGGAGFPSGLKWSFMPKVSDGRPSYLVVNADESEPGTCKDREI
MRHDPHKLLEGCLIAGVGMRATAAYIYIRGEYVNERKNLEKARQEAYAAG
LLGKNACGSGYDFDVHIHFGAGAYICGEETALLESLEGKQGKPRLKPPFP
ANAGLYGCPTTVTNVETVAVSPTILRRGPEWFAGFGRKNNAGTKLFCVSG
HVNKPCTVEEEMSIPLKELIERHCGGVRGGWDNLLAVIPGGSSVPLLPKS
ICDDVLMDYDALKAVQSGLGTAAVIVMDKSTDVVDAIARLSYFYKHESCG
QCTPCREGTGWLWTIMERMKVGNAKLEEIDMLQELTKQIEGHTICALGDA
AAWPVQGLIRHFRPELERRIRENAERELLQATG

3D structure

• PDB: 6x89 Atomic structure of a mitochondrial complex I intermediate from vascular plants.
• Chain: V1
• Resolution: 3.9 Å

Enzymatic activity

• Enzyme Commision number: 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	SF4	V1	I233 P251 S406 Q409 C410 C413 T451 I452 C453 L455	I175 P193 S348 Q351 C352 C355 T393 I394 C395 L397
BS02	FMN	V1	G115 R116 G117 N144 Y232 G235 E236 T271 N272 A454 L455	G57 R58 G59 N86 Y174 G177 E178 T213 N214 A396 L397

Gene Ontology

Molecular Function

• GO:0008137 NADH dehydrogenase (ubiquinone) activity
• GO:0010181 FMN binding
• GO:0046872 metal ion binding
• GO:0051287 NAD binding
• GO:0051539 4 iron, 4 sulfur cluster binding

Biological Process

• GO:0006120 mitochondrial electron transport, NADH to ubiquinone
• GO:1902600 proton transmembrane transport

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0045271 respiratory chain complex I

External links

• PDB: RCSB:6x89, PDBe:6x89, PDBj:6x89
• PDBsum: 6x89
• PubMed: 32840211
• UniProt: A0A1S3V7V2