Structure of PDB 8uha Chain V

Receptor sequence
>8uhaV (length=550) Species: 9606 (Homo sapiens) [Search protein sequence]
LQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLH
GTPRLEFHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLV
KMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQ
ALFGDEVSPLLKQYILEKESALFSTELSVLHNFFSPSPKTRRQGEVVQRL
TRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAELLMSLHDLDVGEIC
TVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGDLSMI
LCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDM
IDSQVFKEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYP
NTLPESFTKFLQEQRMACEVGLYYVLHITKQRNKNALLRLLPGLVETFGD
LAFGDIFLHLLTGNLALLADEFALEDFCSSLFDGFFLTASPRKENVHRHA
LRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHR
3D structure
PDB8uha Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
ChainV
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide V V326 E329 L331 T371 R372 M378 S379 V382 T386 V322 E325 L327 T367 R368 M374 S375 V378 T382
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0008283 cell population proliferation
GO:0034244 negative regulation of transcription elongation by RNA polymerase II
GO:0045892 negative regulation of DNA-templated transcription
GO:0048863 stem cell differentiation
GO:2000737 negative regulation of stem cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0032021 NELF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uha, PDBe:8uha, PDBj:8uha
PDBsum8uha
PubMed38401543
UniProtQ8WX92|NELFB_HUMAN Negative elongation factor B (Gene Name=NELFB)

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