Structure of PDB 8iuh Chain V

Receptor sequence
>8iuhV (length=361) Species: 9606 (Homo sapiens) [Search protein sequence]
RCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTY
SRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSG
IRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQ
IVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTM
QLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLAN
VDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQ
SLVRSAFRDLLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTP
QEVRDFQRAQA
3D structure
PDB8iuh Structure of the SNAPc-bound RNA polymerase III preinitiation complex.
ChainV
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna V S66 S68 R110 L111 K114 S246 Q267 S61 S63 R105 L106 K109 S241 Q262
BS02 dna V R67 G105 A108 R110 K113 R220 Y260 P261 R265 P359 R62 G100 A103 R105 K108 R215 Y255 P256 R260 P313
Gene Ontology
Molecular Function
GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding
GO:0005515 protein binding
GO:0017025 TBP-class protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006352 DNA-templated transcription initiation
GO:0006359 regulation of transcription by RNA polymerase III
GO:0034599 cellular response to oxidative stress
GO:0070897 transcription preinitiation complex assembly
Cellular Component
GO:0000126 transcription factor TFIIIB complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0097550 transcription preinitiation complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8iuh, PDBe:8iuh, PDBj:8iuh
PDBsum8iuh
PubMed37165065
UniProtQ9HAW0|BRF2_HUMAN Transcription factor IIIB 50 kDa subunit (Gene Name=BRF2)

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