Structure of PDB 8ets Chain V

Receptor sequence
>8etsV (length=443) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
VTRTAAHTHIKGLGLDESGVAKRVEGGFVGQIEAREACGVIVDLIKAKKM
SGRAILLAGGPSTGKTALALAISQELGPKVPFCPLVGSELYSVEVKKTET
LMENFRRAIGLRIKETKEVYEGEVTELTPEDAENPLGGYGKTISHVIVGL
KSAKGTKTLRLDPTIYESIQREKVSIGDVIYIEANTGAVKRVGRSDAYAT
EFDLETEEYVPLPKGEVHKKKEIVQDVTLHDLDVANARPQGGQDVISMMG
QLLKPKKTEITEKLRQEVNKVVAKYIDQGVAELIPGVLFIDEVNMLDIEI
FTYLNKALESNIAPVVVLASNRGMTTVRGTEDVISPHGVPPDLIDRLLIV
RTLPYDKDEIRTIIERRATVERLQVESSALDLLATMGTETSLRYALQLLA
PCGILAQTSNRKEIVVNDVNEAKLLFLDAKRSTKILETSANYL
3D structure
PDB8ets Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
ChainV
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide V R214 D216 A217 Y218 F222 D223 R194 D196 A197 Y198 F202 D203
BS02 ADP V A26 H29 G47 V49 P81 S82 T83 G84 K85 T86 Y375 I383 R413 A6 H9 G27 V29 P61 S62 T63 G64 K65 T66 Y355 I363 R393
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032508 DNA duplex unwinding
GO:0050821 protein stabilization
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ets, PDBe:8ets, PDBj:8ets
PDBsum8ets
PubMed37384669
UniProtQ03940|RUVB1_YEAST RuvB-like protein 1 (Gene Name=RVB1)

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