Structure of PDB 8cvs Chain V

Receptor sequence
>8cvsV (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAA
DTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVL
GGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEE
AKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLG
RYRCEKGTTAVLTEKITPLEI
3D structure
PDB8cvs Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
ChainV
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LDZ V T2 T22 K34 G46 A47 G48 A50 T1 T21 K33 G45 A46 G47 A49
BS02 LDZ V Y115 P116 H117 Y114 P115 H116
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8cvs, PDBe:8cvs, PDBj:8cvs
PDBsum8cvs
PubMed35858375
UniProtQ99436|PSB7_HUMAN Proteasome subunit beta type-7 (Gene Name=PSMB7)

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