Structure of PDB 7c07 Chain V

Receptor sequence
>7c07V (length=174) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence]
VNCSFYYKIGACRHGERCSRKHVKPNFSQTILCPNMYKNPIHEKKFTQRE
LAEQFDAFYEDMFCEFSKYGEVEQLVVCDNVGDHLVGNVYVRFKYEESAQ
NAIDDLNSRWYSQRPVYAELSPVTDFREACCRQHETSECQRGGLCNFMHA
KKPSPQLLRDLVLAQRKYLALNAA
3D structure
PDB7c07 Elucidation of the aberrant 3' splice site selection by cancer-associated mutations on the U2AF1.
ChainV
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna V F20 H29 S34 E146 C148 R159 C163 N164 F165 F5 H14 S19 E128 C130 R141 C145 N146 F147
BS02 ZN V C18 C27 C33 H37 C3 C12 C18 H22
BS03 ZN V C149 C163 H167 C131 C145 H149
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030628 pre-mRNA 3'-splice site binding
GO:0046872 metal ion binding
Biological Process
GO:0000389 mRNA 3'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0045292 mRNA cis splicing, via spliceosome
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0071004 U2-type prespliceosome
GO:0089701 U2AF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7c07, PDBe:7c07, PDBj:7c07
PDBsum7c07
PubMed32958768
UniProtQ09176|U2AF1_SCHPO Splicing factor U2AF 23 kDa subunit (Gene Name=SPAP8A3.06)

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