Structure of PDB 6icz Chain V

Receptor sequence
>6iczV (length=452) Species: 9606 (Homo sapiens) [Search protein sequence]
KNSLAYQRMSWEALKKSINGLINKVNISNISIIIQELLQENIVRGRGLLS
RSVLQAQSASPIFTHVYAALVAIINSKFPQIGELILKRLILNFRKGYRRN
DKQLCLTASKFVAHLINQNVAHEVLCLEMLTLLLERPTDDSVEVAIGFLK
ECGLKLTQVSPRGINAIFERLRNILHESEIDKRVQYMIEVMFAVRKDGFK
DHPIILEGLDLVEEDDQFTHMLPLEDDYNPEDVLNVFKMDPNFMENEEKY
KAIKKEILTEINLVSFRRTIYLAIQSSLDFEECAHKLLKMEFPESQTKEL
CNMILDCCAQQRTYEKFFGLLAGRFCMLKKEYMESFEGIFKEQYDTIHRL
ETNKLRNVAKMFAHLLYTDSWSVLECIKLSEETTTSSSRIFVKIFFQELC
EYMGLPKLNARLKDETLQPFFEDNPRNTRFAINFFTSIGLGGLTDELREH
LK
3D structure
PDB6icz Structures of the human spliceosomes before and after release of the ligated exon.
ChainV
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide V E470 H474 L477 K478 R513 E281 H285 L288 K289 R324
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0048024 regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0005829 cytosol
GO:0016607 nuclear speck
GO:0071005 U2-type precatalytic spliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071013 catalytic step 2 spliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6icz, PDBe:6icz, PDBj:6icz
PDBsum6icz
PubMed30728453
UniProtQ9HCG8|CWC22_HUMAN Pre-mRNA-splicing factor CWC22 homolog (Gene Name=CWC22)

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