Structure of PDB 6hvy Chain V

Receptor sequence
>6hvyV (length=226) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWCAGAGTAA
DTEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIV
AGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEE
AIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICDIQEE
3D structure
PDB6hvy Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
ChainV
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1 D17 R19 K33 G47 S129 D166 S169
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S129 D166 S169
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG V I163 W164 D166 I163 W164 D166
BS02 GVZ V T1 S20 T21 C31 H35 G45 A46 G47 A49 T52 G168 T1 S20 T21 C31 H35 G45 A46 G47 A49 T52 G168
BS03 GW2 V T1 S20 T21 C31 K33 H35 G45 A46 G47 A49 T52 T1 S20 T21 C31 K33 H35 G45 A46 G47 A49 T52
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6hvy, PDBe:6hvy, PDBj:6hvy
PDBsum6hvy
PubMed30657666
UniProtP25043|PSB2_YEAST Proteasome subunit beta type-2 (Gene Name=PUP1)

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