Structure of PDB 6hv4 Chain V

Receptor sequence
>6hv4V (length=223) Species: 9606,559292 [Search protein sequence]
TTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAA
DAEAVTQLIGSNIELHSLYTSREPRVVSALQMLKQHLFKYQGHIGAYLIV
AGVDPTGSHLFSIHAHGSTDVGYYLSLGSGSLAAMAVLESHWKQDLTKEE
AIKLASDAIQAGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICDI
3D structure
PDB6hv4 Structure-Based Design of Inhibitors Selective for Human Proteasome beta 2c or beta 2i Subunits.
ChainV
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T1 D17 R19 K33 G47 S129 D166 S169
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S129 D166 S169
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GQK V T1 A20 T21 G47 V48 A49 G168 T1 A20 T21 G47 V48 A49 G168
BS02 MG V I163 W164 D166 I163 W164 D166
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Cellular Component
External links
PDB RCSB:6hv4, PDBe:6hv4, PDBj:6hv4
PDBsum6hv4
PubMed30657666
UniProtP25043|PSB2_YEAST Proteasome subunit beta type-2 (Gene Name=PUP1);
P40306|PSB10_HUMAN Proteasome subunit beta type-10 (Gene Name=PSMB10)

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