Structure of PDB 6gmr Chain V

Receptor sequence
>6gmrV (length=149) Species: 9606 (Homo sapiens) [Search protein sequence]
RPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRI
HSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLK
ERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAH
3D structure
PDB6gmr Surface Probing by Fragment-Based Screening and Computational Methods Identifies Ligandable Pockets on the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase.
ChainV
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide V N67 R69 R79 W88 F91 Y98 P99 G104 T105 G106 R107 R108 H110 S111 Y112 H115 W117 N8 R10 R20 W29 F32 Y39 P40 G45 T46 G47 R48 R49 H51 S52 Y53 H56 W58
BS02 F4K V R120 G127 L128 E134 Y156 E160 R61 G68 L69 E75 Y97 E101
External links
PDB RCSB:6gmr, PDBe:6gmr, PDBj:6gmr
PDBsum6gmr
PubMed30040896
UniProtP40337|VHL_HUMAN von Hippel-Lindau disease tumor suppressor (Gene Name=VHL)

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