Structure of PDB 5txv Chain V

Receptor sequence
>5txvV (length=352) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
SEMTPREIVSELDKHIIGQDNAKRSVAIALRNRWRRMQLNEELRHEVTPK
NILMIGPTGVGKTEIARRLAKLANAPFIKVEATKFTGKEVDSIIRDLTDA
AVKMVRVQAIEKNRYRAEESAARQAFRKKLREGIKDAMKLLIEEEAAKLV
NPEELKQDAIDAVEQHGIVFIDEIDKICPDVSREGVQRDLLPLVEGCTVS
TKHGMVKTDHILFIASGAFQIAKPSDLIPELQGRLPIRVELQALTTSDFE
RILTEPNASITVQYKALMATEGVNIEFTDSGIKRIAEAAWQVNESTENIG
ARRLHTVLERLMEEISYDASDLSGQNITIDADYVSKHLDALVADEDLSRF
IL
3D structure
PDB5txv Covalently linked HslU hexamers support a probabilistic mechanism that links ATP hydrolysis to protein unfolding and translocation.
ChainV
Resolution7.086 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP V I17 I18 T59 G60 V61 G62 K63 T64 E65 R393 I16 I17 T58 G59 V60 G61 K62 T63 E64 R302
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004176 ATP-dependent peptidase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008233 peptidase activity
GO:0016887 ATP hydrolysis activity
GO:0019904 protein domain specific binding
GO:0036402 proteasome-activating activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0009408 response to heat
GO:0030164 protein denaturation
GO:0034605 cellular response to heat
GO:0043335 protein unfolding
GO:0051603 proteolysis involved in protein catabolic process
GO:1901800 positive regulation of proteasomal protein catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009376 HslUV protease complex
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5txv, PDBe:5txv, PDBj:5txv
PDBsum5txv
PubMed28223361
UniProtP0A6H5|HSLU_ECOLI ATP-dependent protease ATPase subunit HslU (Gene Name=hslU)

[Back to BioLiP]