Structure of PDB 5lf7 Chain V

Receptor sequence
>5lf7V (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
TTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAA
DTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVL
GGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEE
AKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLG
RYRCEKGTTAVLTEKITPLE
3D structure
PDB5lf7 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
ChainV
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T2 D18 R20 K34 G48 S130 D167 S170
Catalytic site (residue number reindexed from 1) T1 D17 R19 K33 G47 S129 D166 S169
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG V I164 D167 S170 I163 D166 S169
BS02 6V8 V T2 A21 T22 E23 A47 G48 A50 T1 A20 T21 E22 A46 G47 A49
Gene Ontology
Molecular Function
GO:0004298 threonine-type endopeptidase activity
Biological Process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0005839 proteasome core complex

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Cellular Component
External links
PDB RCSB:5lf7, PDBe:5lf7, PDBj:5lf7
PDBsum5lf7
PubMed27493187
UniProtQ99436|PSB7_HUMAN Proteasome subunit beta type-7 (Gene Name=PSMB7)

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