Structure of PDB 4bxs Chain V

Receptor sequence

>4bxsV (length=1262) Species: 8673 (Pseudonaja textilis)

AQLREYHIAAQLEDWDYNPQLTFKKIVYREYELDFKQEKPRDALSGLLGP
TLRGEVGDSLIIYFKNFATQPVSIHPQSAVYNKWSEGSSYSDGTSDVERL
DDAVPPGQSFKYVWNITAEIGPKKADPPCLTYAYYSHVNMVRDFNSGLIG
ALLICKEGSLNANGSQKFFNREYVLMFSVFDESKNWYRKPSLQYTINGFA
NGTLPDVQACAYDHISWHLIGMSSSPEIFSVHFNGQTLEQNHYKVSTINL
VGGASVTADMSVSRTGKWLISSLVAKHLQAGMYGYLNIKDCGNPDMKIKN
WEYFIAAEEITWDYAPEIPSSVDRRYKAQYLDNFSNFIGKKYKKAVFRQY
EDGNFTKPTYAIWPKERGILGPVIKAKVRDTVTIVFKNLASRPYSIYVHG
VSVSKDAEGAIYPSDPTHGKAVEPGQVYTYKWTVLDTDEPTVKDSECITK
LYHSAVDMTRDIASGLIGPLLVCKHKALSGVQNKADVEQHAVFAVFDENK
SWYLEDNIKKYCSNPSAVKKDDPKFYKSNVMYTLNGYASDRTEVLRFHQS
EVVQWHLTSVGTVDEIVPVHLSGHTFLSKGKHQDILNLFPMSGESATVTM
DNLGTWLLSSWGSCEMSNGMRLRFLDANYDDEDEGNEEEEEDDGDIFADI
FIPSEGNKRRYYIAAEEVLWDYSPKTTFKKAIFRSYLDDTFQTPSTGGEY
EKHLGILGPIIRAEVDDVIEIQFKNLASRPYSLHAHGLLYEKSSEGRSYD
DKSPELFKKDDAIMPNGTYTYVWQVPPRSGPTDNTEKCKSWAYYSGVNPE
KDIHSGLIGPILICQKGMIDKYNRTIDIREFVLFFMVFDEEKSWYFPCSL
HTFPAINGIPYQLQGLTMYKDENVHWHLLNMGGPKDIHVVNFHGQTFTEE
GREDNQLGVLPLLPGTFASIKMKPSKIGTWLLETEVGENQERGMQALFTV
IDKDCKLPMGLASGIIQDSQISASGHVGYWEPKLARLNNTGKYNAWSIIK
KEHEHPWIQIDLQRQVVITGIQTQGTVQLLQHSYTVEYFVTYSEDGQNWI
TFKGQMHFEGNSDGTTVKENHIDPPIIARYIRLHPTKFYNRPTFRIELLG
CEVEGCSVPLGMESGAIKNKEITASSYKKTWWSSWEPFLARLNLEGGTNA
WQPEVNNKDQWLQIDLQHLTKITSIITQGATSMTTSMYVKTFSIHYTDDN
STWKPYLDVRTSMEKVFTGNINSDGHVKHFFKPPILSRFIRIIPKTWNQY
IALRIELFGCEV

3D structure

• PDB: 4bxs Crystal Structure of the Prothrombinase Complex from the Venom of Pseudonaja Textilis.
• Chain: V
• Resolution: 3.32 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	V	D192 S236	D181 S225
BS02	CA	V	K94 E109 D112 D113	K83 E98 D101 D102
BS03	CA	V	K890 E893 F905 D908 D909	K742 E745 F757 D760 D761
BS04	CU	V	H148 H1055 E1095	H137 H893 E933

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0005507 copper ion binding
• GO:0005515 protein binding
• GO:0016504 peptidase activator activity
• GO:0038023 signaling receptor activity
• GO:0046872 metal ion binding
• GO:0090729 toxin activity

Biological Process

• GO:0010952 positive regulation of peptidase activity
• GO:0035807 induction of blood coagulation in another organism
• GO:0044469 envenomation resulting in positive regulation of blood coagulation in another organism

Cellular Component

• GO:0005576 extracellular region
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:4bxs, PDBe:4bxs, PDBj:4bxs
• PDBsum: 4bxs
• PubMed: 23869089
• UniProt: Q7SZN0|FA5V_PSETE Venom prothrombin activator pseutarin-C non-catalytic subunit