Structure of PDB 4adv Chain V

Receptor sequence
>4advV (length=252) Species: 562 (Escherichia coli) [Search protein sequence]
QNFLNDQFVIDSIVSAINPQKGQAMVEIGPGLAALTEPVGERLDQLTVIE
LDRDLAARLQTHPFLGPKLTIYQQDAMTFNFGELAEKMGQPLRVFGNLPY
NISTPLMFHLFSYTDAIADMHFMLQKEVVNRLVAGPNSKAYGRLSVMAQY
YCNVIPVLEVPPSAFTPPPKVDSAVVRLVPHATMPHPVKDVRVLSRITTE
AFNQRRKTIRNSLGNLFSVEVLTGMGIDPAMRAENISVAQYCQMANYLAE
NA
3D structure
PDB4adv Structural Insights Into Methyltransferase Ksga Function in 30S Ribosomal Subunit Biogenesis
ChainV
Resolution13.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G45 E66 N113 Y116 F181
Catalytic site (residue number reindexed from 1) G29 E50 N97 Y100 F165
Enzyme Commision number 2.1.1.182: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna V Y116 N117 Q141 E143 V144 R147 P185 K186 V187 D188 R222 Y100 N101 Q125 E127 V128 R131 P169 K170 V171 D172 R206
Gene Ontology
Molecular Function
GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0008168 methyltransferase activity
GO:0016433 rRNA (adenine) methyltransferase activity
GO:0043024 ribosomal small subunit binding
GO:0052908 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Biological Process
GO:0000028 ribosomal small subunit assembly
GO:0000154 rRNA modification
GO:0006364 rRNA processing
GO:0030490 maturation of SSU-rRNA
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0046677 response to antibiotic
GO:0070475 rRNA base methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4adv, PDBe:4adv, PDBj:4adv
PDBsum4adv
PubMed22308031
UniProtP06992|RSMA_ECOLI Ribosomal RNA small subunit methyltransferase A (Gene Name=rsmA)

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