Structure of PDB 6zqc Chain UR

Receptor sequence

>6zqcUR (length=482) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

PPPDEEEQLLAKFVFGDTTDLQENLAKFNADFIEAAWIDSDDEKIKVPIL
VTNKTKKLRTSYNESKINGVHYINRLRSQFEKIYPRPKWVDDESDSNGDI
NALTKILSTTYNYKDTLSNSKLLPPKKLDIVRLKDANASHPSHSAIQSLS
FHPSKPLLLTGGYDKTLRIYHIDGKTNHLVTSLHLVGSPIQTCTFYTSLS
NQNQQNIFTAGRRRYMHSWDLSQTAKIEKFSRLYGHESTQRSFENFKVAH
LQNSQTNSVHGIVLLQGNNGWINILHSTSGLWLMGCKIEGVITDFCIDYQ
PISRGKFRTILIAVNAYGEVWEFDLNKNGHVIRRWKDQGGVGITKIQVGG
GTTTTCPALQISKIKQNRWLAVGSESGFVNLYDRNNAMTSSTPTPVAALD
QLTTTISNLQFSPDGQILCMASRAVKDALRLVHLPSCSVFSNWPTSGTPL
GKVTSVAFSPSGGLLAVGNEQGKVRLWKLNHY

3D structure

PDB

6zqc 90 S pre-ribosome transformation into the primordial 40 S subunit.

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	UR	N141 K144 K145 R147 Y150 Q167 D234 I235 R237 Q252 R317 R318 R319 Y320 K341 S343 R344 S354 N380 N381 T517 R535 A536 K538 T557 S558 G559 T560 P561 E582 Q583	N53 K56 K57 R59 Y62 Q79 D129 I130 R132 Q147 R212 R213 R214 Y215 K229 S231 R232 S242 N268 N269 T405 R423 A424 K426 T445 S446 G447 T448 P449 E470 Q471
BS02	rna	UR	K231 Q513 R542	K126 Q401 R430

Gene Ontology

	Molecular Function
GO:0003674	molecular_function
GO:0005515	protein binding

	Biological Process
GO:0000292	RNA fragment catabolic process
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0030490	maturation of SSU-rRNA
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0030686	90S preribosome
GO:0032040	small-subunit processome
GO:0034388	Pwp2p-containing subcomplex of 90S preribosome
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:6zqc, PDBe:6zqc, PDBj:6zqc
PDBsum	6zqc
PubMed	32943521
UniProt	P40362\|UTP18_YEAST U3 small nucleolar RNA-associated protein 18 (Gene Name=UTP18)

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