Structure of PDB 7aju Chain UQ

Receptor sequence

>7ajuUQ (length=820) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]

QYKLSVVSGGKPALNNLSSVTGNKNIARLSQDQRNYIIPFNNQIKVYSVE
TRQCVKTLKFANNSLLSGIFLQEEENNESIVKILLGDITVPQQAHLITVF
TNNGHVIVLNYKGKLVESPKHFKISLADEKLANVFHSEGNYRILTTFKDN
SLQSYRLYALTFDDAKKQFEVAHQAEWHNVILSNISSNGKLLAHMCKDVS
TKDHEHKSISVVSLFDDSVNLSFPLGSILSSQTQSLSYNTRYVSSMAIDN
MGQQLAVGFASGVISIVSLADLQIRLLKWHIDSVLSLSFSHDGSYLLSGG
WEKVMSLWQLETNSQQFLPRLNGIIIDCQVLGPQGNYYSLILQMTENNSN
SDYQFLLLNASDLTSKLSINGPLPVFNSTIKHIQQPISAMNTKNSNSITS
LNHSKKKQSRKLIKSRRQDFTTNVEINPINKNLYFPHISAVQIFDFYKNE
QVNYQYLTSGVNNSMGKVRFELNLQDPIITDLKFTKDGQWMITYEIEYPP
NDLLSSKDLTHILKFWTKNDNETNWNLKTKVINPHGISVPITKILPSPRS
VNNSQGCLTADNNGGLKFWSFDSHESNWCLKKISLPNFNHFSNSVSLAWS
QDGSLIFHGFDDKLQILDFDTFKKFESLENTKTVSEFTLDSEIQTVKLIN
DTNLIVATRTTLNAINLLRGQVINSFDLYPFVNGVYKNGHMDRLITCDER
TGNIALVINQQLTDVPTINYKSRIIIFDSDLSTKLGNFTHHEYISWIGWN
YDTDFIFLDIESTLGVVGTNDEDEEDIALEFINGEKKDKLVNMNSFTSMF
DNIQNVQMDTFFDRVMKVLT

3D structure

PDB

7aju Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.

Chain

Resolution

3.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	UQ	N166 S167 L168 I197 H220 H222 K223 Q248 T249 L252 S253 Y254 Y258 V259 F275 V279 K294 W295 I297 E318 V320 Q332 F333 P335 I414 T415 R426 K427 K430 R433 G482 V484 S554 P556 F607 S608 N609	N150 S151 L152 I181 H204 H206 K207 Q232 T233 L236 S237 Y238 Y242 V243 F259 V263 K278 W279 I281 E302 V304 Q316 F317 P319 I398 T399 R410 K411 K414 R417 G466 V468 S538 P540 F591 S592 N593
BS02	rna	UQ	N868 M869	N792 M793

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0034511	U3 snoRNA binding

	Biological Process
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006364	rRNA processing
GO:0030490	maturation of SSU-rRNA
GO:0042254	ribosome biogenesis
GO:0045943	positive regulation of transcription by RNA polymerase I
GO:2000234	positive regulation of rRNA processing

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005777	peroxisome
GO:0030686	90S preribosome
GO:0032040	small-subunit processome
GO:0033553	rDNA heterochromatin
GO:0034455	t-UTP complex
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7aju, PDBe:7aju, PDBj:7aju
PDBsum	7aju
PubMed	33326748
UniProt	Q02931\|UTP17_YEAST NET1-associated nuclear protein 1 (Gene Name=NAN1)

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