Structure of PDB 8y6o Chain U

Receptor sequence
>8y6oU (length=458) Species: 9606 (Homo sapiens) [Search protein sequence]
RRSRHCPYLDTINRSVLDFDFEKLCSISLSHINAYACLVCGKYFQGRGLK
SHAYIHSVQFSHHVFLNLHTLKFYCLPDNYEIIDSSLEDITYVLKPTFTK
QQIANLDKQAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPL
RNYFLEEDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEM
LQAVVLCSKKTFQITKQGDGVDFLSWFLNALHSALGGTKKKKKTIVTDVF
QGSMRIFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLDLPTAP
LYKDEKEQLIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPY
LIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLSEEVQAVHKNTTYDL
IANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDILPQMITLSEAYI
QIWKRRDN
3D structure
PDB8y6o Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
ChainU
Resolution3.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN U C136 H155 H161 C37 H56 H62
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000245 spliceosomal complex assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0016579 protein deubiquitination
GO:0051301 cell division
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005681 spliceosomal complex
GO:0046540 U4/U6 x U5 tri-snRNP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8y6o, PDBe:8y6o, PDBj:8y6o
PDBsum8y6o
PubMed38484052
UniProtQ53GS9|UBP39_HUMAN Ubiquitin carboxyl-terminal hydrolase 39 (Gene Name=USP39)

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