Structure of PDB 8y38 Chain U

Receptor sequence

>8y38U (length=82) Species: 1280 (Staphylococcus aureus) [Search protein sequence]

KKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGR
GGDDTLFAKIDGVVKFERKGRDKKQVSVYAVA

3D structure

PDB

8y38 Synthetic macrolides overcoming MLS B K-resistant pathogens.

Chain

Resolution

2.58 Å

3D
structure

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	U	K12 G14 V15 S16 S17 T18 N20 R22 D23 S24 E25 S26 K27 R28 K32 R33 A34 D35 G36 Q37 T40 G41 G42 S43 I44 Y46 R47 R49 G50 T51 Y54 G62 G63 D64 D65 T66 F68 K70 K84 K85	K1 G3 V4 S5 S6 T7 N9 R11 D12 S13 E14 S15 K16 R17 K21 R22 A23 D24 G25 Q26 T29 G30 G31 S32 I33 Y35 R36 R38 G39 T40 Y43 G51 G52 D53 D54 T55 F57 K59 K73 K74
BS02	rna	U	R79 G81 R82	R68 G70 R71

External links

PDB	RCSB:8y38, PDBe:8y38, PDBj:8y38
PDBsum	8y38
PubMed	38992047
UniProt	P66134\|RL27_STAAW Large ribosomal subunit protein bL27 (Gene Name=rpmA)