Structure of PDB 8ir3 Chain U

Receptor sequence

>8ir3U (length=203) Species: 9606 (Homo sapiens)

GAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARRL
GYKAKQGYVIYRIRVRRGGRKRPVPKGATYGKPVHHGVNQLKFARSLQSV
AEERAGRHCGALRVLNSYWVGEDSTYKFFEVILIDPFHKAIRRNPDTQWI
TKPVHKHREMRGLTSAGRKSRGLGKGHKFHHTIGGSRRAAWRRRNTLQLH
RYR

3D structure

• PDB: 8ir3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
• Chain: U
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	U	R38 Q57 V60 Y62	R37 Q56 V59 Y61
BS02	rna	U	G2 Y4 K5 R12 K14 Q15 R24 R31 A35 R41 R44 K47 R49 R50 L51 K54 A55 R65 R67 R68 G69 R71 K72 R73 V75 K77 Y81 G82 K83 V85 Q91 K93 F94 A95 R96 R105 R108 W120 K128 F138 R144 W150 P154 K157 M161 R162 S166 R169 S171 R172 K176 H178 K179 H181 H182 I184 G186 S187 R189 W192 R193 R194 R195 H201 R202 R204	G1 Y3 K4 R11 K13 Q14 R23 R30 A34 R40 R43 K46 R48 R49 L50 K53 A54 R64 R66 R67 G68 R70 K71 R72 V74 K76 Y80 G81 K82 V84 Q90 K92 F93 A94 R95 R104 R107 W119 K127 F137 R143 W149 P153 K156 M160 R161 S165 R168 S170 R171 K175 H177 K178 H180 H181 I183 G185 S186 R188 W191 R192 R193 R194 H200 R201 R203

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding
• GO:0045296 cadherin binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation
• GO:0045471 response to ethanol

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0022626 cytosolic ribosome
• GO:0031672 A band
• GO:0044391 ribosomal subunit
• GO:0045202 synapse
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8ir3, PDBe:8ir3, PDBj:8ir3
• PDBsum: 8ir3
• PubMed: 37491604
• UniProt: P61313|RL15_HUMAN Large ribosomal subunit protein eL15 (Gene Name=RPL15)