Structure of PDB 8ets Chain U

Receptor sequence
>8etsU (length=436) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KSLSLIAAHSHITGLGLDENLQPRPTSEGMVGQLQARRAAGVILKMVQNG
TIAGRAVLVAGPPSTGKTALAMGVSQSLGKDVPFTAIAGSEIFSLELSKT
EALTQAFRKSIGIKIKEETELIEGEVVEIQIDRSITGGHKQGKLTIKTTD
METIYELGNKMIDGLTKEKVLAGDVISIDKASGKITKLGRSFARSRFVQC
PEGELQKRKTVVHTVSLHEIDVINSRTQGFLALFTGDTGEIRSEVRDQIN
TKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSFINRALEDEFAPIVMMA
TNRGVSKTRGTNYKSPHGLPLDLLDRSIIITTKSYNEQEIKTILSIRAQE
EEVELSSDALDLLTKTGVETSLRYSSNLISVAQQIAMKRKNNTVEVEDVK
RAYLLFLDSARSVKYVQENESQYIDDQGNVQISIAK
3D structure
PDB8ets Reorientation of INO80 on hexasomes reveals basis for mechanistic versatility.
ChainU
Resolution3.04 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP U H23 H25 M44 V45 P77 S78 G80 K81 Y359 R397 H9 H11 M30 V31 P63 S64 G66 K67 Y335 R373
Gene Ontology
Molecular Function
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 ATP-dependent activity, acting on DNA
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0043138 3'-5' DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006281 DNA repair
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006364 rRNA processing
GO:0032508 DNA duplex unwinding
GO:0050821 protein stabilization
Cellular Component
GO:0000785 chromatin
GO:0000812 Swr1 complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0097255 R2TP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ets, PDBe:8ets, PDBj:8ets
PDBsum8ets
PubMed37384669
UniProtQ12464|RUVB2_YEAST RuvB-like protein 2 (Gene Name=RVB2)

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