Structure of PDB 7r47 Chain U

Receptor sequence
>7r47U (length=84) Species: 9913 (Bos taurus) [Search protein sequence]
PLTLEGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAM
EDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
3D structure
PDB7r47 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
ChainU
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EHZ U D43 S44 D39 S40
Gene Ontology
Molecular Function
GO:0000035 acyl binding
GO:0000036 acyl carrier activity
GO:0005504 fatty acid binding
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016491 oxidoreductase activity
GO:0140978 mitochondrial large ribosomal subunit binding
Biological Process
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0006633 fatty acid biosynthetic process
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0044571 [2Fe-2S] cluster assembly
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0031966 mitochondrial membrane
GO:0045271 respiratory chain complex I
GO:1902494 catalytic complex

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Cellular Component
External links
PDB RCSB:7r47, PDBe:7r47, PDBj:7r47
PDBsum7r47
PubMed36701435
UniProtP52505|ACPM_BOVIN Acyl carrier protein, mitochondrial (Gene Name=NDUFAB1)

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