Structure of PDB 7k5x Chain U

Receptor sequence

>7k5xU (length=74) Species: 9606 (Homo sapiens) [Search protein sequence]

DHPKYSDMIVAAIQAEKNRAGSSRQSIQKYIKSHYKVGENADSQIKLSIK
RLVTTGVLKQTKGVGASGSFRLAK

3D structure

PDB

7k5x Distinct Structures and Dynamics of Chromatosomes with Different Human Linker Histone Isoforms.

Chain

Resolution

2.93 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	U	H24 Y27 S45 Q47 Q66 R73 K84 S91	H2 Y5 S23 Q25 Q44 R51 K62 S69
BS02	dna	U	R46 S65 K68 A88 S89	R24 S43 K46 A66 S67

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003680	minor groove of adenine-thymine-rich DNA binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0030527	structural constituent of chromatin
GO:0031490	chromatin DNA binding
GO:0031491	nucleosome binding
GO:0031492	nucleosomal DNA binding

	Biological Process
GO:0006334	nucleosome assembly
GO:0030261	chromosome condensation
GO:0031507	heterochromatin formation
GO:0045910	negative regulation of DNA recombination
GO:2000679	positive regulation of transcription regulatory region DNA binding

	Cellular Component
GO:0000785	chromatin
GO:0000786	nucleosome
GO:0000791	euchromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005794	Golgi apparatus
GO:0015629	actin cytoskeleton
GO:0016604	nuclear body
GO:0017053	transcription repressor complex

External links