Structure of PDB 6ri5 Chain U

Receptor sequence

>6ri5U (length=154) Species: 4932 (Saccharomyces cerevisiae)

ARYGATSTNPAKSASARGSYLRVSFKNTRETAQAINGWELTKAQKYLEQV
LDHQRAIPFRRFNSSIGRTAQGKEFGVTKARWPAKSVKFVQGLLQNAAAN
AEAKGLDATKLYVSHIQVNQAPKQRRRTYRAHGRINKYESSPSHIELVVT
EKEE

3D structure

• PDB: 6ri5 Mechanism of completion of peptidyltransferase centre assembly in eukaryotes.
• Chain: U
• Resolution: 3.3 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	U	Y4 S16 R18 Y21 R23 S25 F26 K27 N28 R30 Q34 Q50 R62 F63 S65 S66 I67 G68 R69 T70 A71 K80 R82 W83 P84 K86 N97 N101 H116 Q118 V119 R127 T129 Y130 R131 A132 H133 G134 N137 K138 Y139 E140 S141 S142	Y3 S15 R17 Y20 R22 S24 F25 K26 N27 R29 Q33 Q49 R61 F62 S64 S65 I66 G67 R68 T69 A70 K79 R81 W82 P83 K85 N96 N100 H115 Q117 V118 R126 T128 Y129 R130 A131 H132 G133 N136 K137 Y138 E139 S140 S141
BS02	rna	U	R3 R61 R62 N120 Q121 H145	R2 R60 R61 N119 Q120 H144

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:0030687 preribosome, large subunit precursor
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6ri5, PDBe:6ri5, PDBj:6ri5
• PDBsum: 6ri5
• PubMed: 31115337
• UniProt: P05740|RL17A_YEAST Large ribosomal subunit protein uL22A (Gene Name=RPL17A)