Structure of PDB 6fdz Chain U

Receptor sequence
>6fdzU (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
PPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVE
NLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDLSRFIHTRR
ILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLEKPHLKLAD
FGFAQHMSPWDEKHVLRGSPLYMAPEMVCQYDARVDLWSMGVILYEALFG
QPPFASRSFSELEEKIRSNRVIELPLRPLLSRDCRDLLQRLLERDPSRRI
SFQDFFAHPWVDLEH
3D structure
PDB6fdz Unc-51-Like Kinase 3 (ULK3) In Complex With Momelotinib
ChainU
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 Q141 N142 D157 S176
Catalytic site (residue number reindexed from 1) D130 K132 Q134 N135 D150 S169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C87 U S22 A26 V28 A42 K44 M91 F93 C94 G97 L144 F158 S15 A19 V21 A35 K37 M84 F86 C87 G90 L137 F151
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0010506 regulation of autophagy

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Molecular Function
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Biological Process
External links
PDB RCSB:6fdz, PDBe:6fdz, PDBj:6fdz
PDBsum6fdz
PubMed
UniProtQ6PHR2|ULK3_HUMAN Serine/threonine-protein kinase ULK3 (Gene Name=ULK3)

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