Structure of PDB 5vk0 Chain U

Receptor sequence
>5vk0U (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV
3D structure
PDB5vk0 Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.
ChainU
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U E25 F55 Y56 Q59 E1 F31 Y32 Q35
BS02 peptide U L54 L57 G58 I61 Y67 Q72 V93 K94 H96 I99 L30 L33 G34 I37 Y43 Q48 V69 K70 H72 I75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5vk0, PDBe:5vk0, PDBj:5vk0
PDBsum5vk0
PubMed30809370
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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