Structure of PDB 4zkn Chain U

Receptor sequence
>4zknU (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADLAHHNDIALL
KIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLYP
EQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGP
LVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB4zkn The crystal structure of mupain-1-IG in complex with murinised human uPA at pH7.4
ChainU
Resolution1.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U R35 H57 C58 D60A Y60B H99 D189 S190 C191 Q192 G193 S195 W215 G219 R20 H46 C47 D50 Y51 H93 D191 S192 C193 Q194 G195 S197 W217 G220
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4zkn, PDBe:4zkn, PDBj:4zkn
PDBsum4zkn
PubMed
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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