Structure of PDB 4x1s Chain U

Receptor sequence
>4x1sU (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAYHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTK
3D structure
PDB4x1s A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
ChainU
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U R35 Y40 V41 H57 C58 D97 T97A L97B Y99 Y151 Q192 G193 S195 W215 G216 R217 R20 Y29 V30 H46 C47 D90 T91 L92 Y94 Y150 Q195 G196 S198 W218 G219 R220
BS02 MRZ U D189 S190 W215 G216 G219 D192 S193 W218 G219 G221
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x1s, PDBe:4x1s, PDBj:4x1s
PDBsum4x1s
PubMed25545505
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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