Structure of PDB 4x1r Chain U

Receptor sequence
>4x1rU (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAYHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
3D structure
PDB4x1r A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
ChainU
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U R35 C42 H57 C58 D97 T97A L97B Y99 Y151 Q192 W215 G216 R217 R20 C31 H46 C47 D90 T91 L92 Y94 Y150 Q195 W218 G219 R220
BS02 PL0 U D189 S190 C191 W215 G216 G219 D192 S193 C194 W218 G219 G221 BindingDB: IC50=20000nM,Ki=20600nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x1r, PDBe:4x1r, PDBj:4x1r
PDBsum4x1r
PubMed25545505
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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