Structure of PDB 4x1n Chain U

Receptor sequence
>4x1nU (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAYHNDIAL
LKIRSKEGRCAQPSRTIQTIALPSMYNDPQFGTSCEITGFGKEQSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
3D structure
PDB4x1n A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility.
ChainU
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide U R35 Y40 V41 H57 C58 D97 T97A L97B Y99 Q192 S195 W215 G216 R217 R20 Y29 V30 H46 C47 D90 T91 L92 Y94 Q195 S198 W218 G219 R220
BS02 MRZ U D189 S190 W215 G216 G219 G226 D192 S193 W218 G219 G221 G229
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:4x1n, PDBe:4x1n, PDBj:4x1n
PDBsum4x1n
PubMed25545505
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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