Structure of PDB 3sdi Chain U

Receptor sequence
>3sdiU (length=240) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DRHITIFSPEGRLYQVEYAFKATNQTNINSLAVRGKDCTVVISQKKVPDK
LLDPTTVSYIFCISRTIGMVVNGPIPDARNAALRAKAEAAEFRYKYGYDM
PCDVLAKRMANLSQIYTQRAYMRPLGVILTFVSVDEELGPSIYKTDPAGY
YVGYKATATGPKQQEITTNLENHFKKSKIDHINEESWEKVVEFAITHMID
ALGTEFSKNDLEVGVATKDKFFTLSAENIEERLVAIAEQD
3D structure
PDB3sdi Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome.
ChainU
Resolution2.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.4.25.1: proteasome endopeptidase complex.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG U A127 Y128 A120 Y121
BS02 MG U T13 Y123 R126 M129 T5 Y116 R119 M122
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010499 proteasomal ubiquitin-independent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051603 proteolysis involved in protein catabolic process
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005839 proteasome core complex
GO:0019773 proteasome core complex, alpha-subunit complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3sdi, PDBe:3sdi, PDBj:3sdi
PDBsum3sdi
PubMed20875739
UniProtP21243|PSA1_YEAST Proteasome subunit alpha type-1 (Gene Name=SCL1)

[Back to BioLiP]