Structure of PDB 3icq Chain U

Receptor sequence
>3icqU (length=943) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence]
SAQDVENAVEAALGPIIKQQATDFIGSLRSSSTGWKICHEIFSEKTKYKP
STRLICLQTLSEKVREWNNESNLLELQMIRDSVWSYIKELSFLDEPAYIS
NAVQHLLTLLFLQLYPSNWNDFFASLQGVIAASSQSEFSNFYLKVLLSIG
DEIADSLVLKTDVQIQKDNLVKDAIRANDMSDIVSFVYEMMLAYSNAKNY
GTVGLCLQVYAQWVSWININLIVNEPCMNLLYSFLQIEELRCAACETMTE
IVNKKMKPLEKLNLLNILNLNLFFSKSSTDPNFDEHVAKLINAQGVELVA
IKSDPSELSPELKENCSFQLYNLFPYLIRYLSDDYDETSTAVFPFLSDLL
VSLRKESSSKELSASLKEFLKSLLEAIIKKMKYDESQEWDDDPDSEEEAE
FQEMRKKLKIFQDTINSIDSSLFSSYMYSAITSSLSTAATLSPENSWQLI
EFALYETYIFGEGLRGPDAFFNEVDKSPTVLSQILALVTTSQVCRHPHPL
VQLLYMEILVRYASFFDYESAAIPALIEYFVGPRGIHNTNERVRPRAWYL
FYRFVKSIKKQVVNYTESSLAMLGDLLNISVSPVTDMDAPVPTLNSSIRN
SDFNSQLYLFETVGVLISSGNLTPEEQALYCDSLINALIGKANAALSSDL
SALENIISVYCSLMAIGNFAKGFPARGSEEVAWLASFNKASDEIFLILDR
MGFNEDIRGAVRFTSGRIINVVGPDMLPKVPQLISILLNSIDMNELVDVL
SFISQLIHIYKDNMMEITNRMLPTLLMRIFSSLSAAPQGTDDAVKQNDLR
KSYISFILQLLNKGFGSILFTEENQVYFDPLINSILHFANLVPATQKSSI
ALVSKMVSLWGGKGFENFTLSLTPLCFEMPVNPNQSLVVLGELAGLQKII
LEKLYKSYLVTVYFPTVSEYLQALSDSRSFKQFFQKFIQALKS
3D structure
PDB3icq Structures of the tRNA export factor in the nuclear and cytosolic states
ChainU
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna U K177 R181 S220 W221 K259 K260 E470 G471 L472 R473 K679 R725 Q763 H766 K172 R176 S215 W216 K254 K255 E462 G463 L464 R465 K671 R717 Q755 H758
BS02 GTP U T798 D799 T790 D791
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0031267 small GTPase binding
Biological Process
GO:0006409 tRNA export from nucleus
GO:0008033 tRNA processing
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016363 nuclear matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3icq, PDBe:3icq, PDBj:3icq
PDBsum3icq
PubMed19680239
UniProtO94258|XPOT_SCHPO Exportin-T (Gene Name=los1)

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