Structure of PDB 3f9k Chain U

Receptor sequence
>3f9kU (length=204) Species: 11720 (Human immunodeficiency virus type 2 (ISOLATE ROD)) [Search protein sequence]
KIEPAQEEHEKYHSNVKELSHKFGIPNLVARQIVNSCAQCQQKGEAIHGQ
VNAELGTWQMDCTHLEGKIIIVAVHVASGFIEAEVIPQESGRQTALFLLK
LASRWPITHLHTDNGANFTSQEVKMVAWWIGIEQSFGVPYNPQSQGVVEA
MNHHLKNQISRIREQANTIETIVLMAVHCMNFKRRGGIGDMTPSERLINM
ITTE
3D structure
PDB3f9k A novel co-crystal structure affords the design of gain-of-function lentiviral integrase mutants in the presence of modified PSIP1/LEDGF/p75
ChainU
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.47: HIV-2 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN U H12 H16 C40 C43 H9 H13 C37 C40
BS02 MG U D64 D116 D61 D113
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3f9k, PDBe:3f9k, PDBj:3f9k
PDBsum3f9k
PubMed19132083
UniProtP04584|POL_HV2RO Gag-Pol polyprotein (Gene Name=gag-pol)

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