Structure of PDB 2xct Chain U

Receptor sequence
>2xctU (length=665) Species: 158879 (Staphylococcus aureus subsp. aureus N315) [Search protein sequence]
LADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKA
RLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIR
TLLLTFFYRFMRPLIEAGYVYIAQPPTKGLGEMNADQLWETTMNPEHRAL
LQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYNITSEMRESFLDYA
MSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGDVMG
KYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRFTEA
RMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIA
VGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILG
KSGIRRAYETGRGSIQMRSRAVIEERGGGRQRIVVTEIPFQVNKARMIEK
IAELVRDKKIDGITDLRDETSLRTGVRVVIDVRKDANASVILNNLYKQTP
LQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKD
RAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQRFKLSEKQAQAIL
DMRLRRLTGLERDKIEAEYNELLNYISELETILADEEVLLQLVRDELTEI
RDRFGDDRRTEIQLG
3D structure
PDB2xct Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
ChainU
Resolution3.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna U K460 D512 K43 D95
BS02 dna U R1033 H1046 H1081 S1085 R1092 I1175 R1272 R207 H220 H255 S259 R266 I349 R446
BS03 dna U D437 S438 R1122 I1175 V1177 G1178 M1179 R1238 D20 S21 R296 I349 V351 G352 M353 R412
BS04 dna U L462 N463 K466 H515 V626 R629 L45 N46 K49 H98 V173 R176
BS05 MN U D508 D510 D91 D93
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2xct, PDBe:2xct, PDBj:2xct
PDBsum2xct
PubMed20686482
UniProtP66937|GYRB_STAAN DNA gyrase subunit B (Gene Name=gyrB);
Q99XG5|GYRA_STAAN DNA gyrase subunit A (Gene Name=gyrA)

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