Structure of PDB 2r2w Chain U

Receptor sequence
>2r2wU (length=247) Species: 9606 (Homo sapiens) [Search protein sequence]
IIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID
YPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIAL
LKIRSKEGRCAQPSRTIQTISLPSMYNDPQFGTSCEITGFGKENSTDYLY
PEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGG
PLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKE
3D structure
PDB2r2w Geometry of GPPE binding to picrate and to the urokinase type plasminogen activator.
ChainU
Resolution2.01 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.73: u-plasminogen activator.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4PG U H57 H99 D189 S190 Q192 S195 W215 G216 G219 G226 H46 H94 D192 S193 Q195 S198 W218 G219 G221 G229 MOAD: Ki=34uM
PDBbind-CN: -logKd/Ki=4.47,Ki=34uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2r2w, PDBe:2r2w, PDBj:2r2w
PDBsum2r2w
PubMed17905583
UniProtP00749|UROK_HUMAN Urokinase-type plasminogen activator (Gene Name=PLAU)

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