Structure of PDB 8i7o Chain TI

Receptor sequence
>8i7oTI (length=438) Species: 10090 (Mus musculus) [Search protein sequence]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFN
TFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAA
NNYARGHYTIGKEIVDLVLDRIRKLADLCTGLQGFLIFHSFGGGTGSGFA
SLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDC
AFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNV
DLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTG
FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGVD
3D structure
PDB8i7o In-cell structural insight into the stability of sperm microtubule doublet
ChainTI
Resolution4.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP TI G10 Q11 A12 Q15 I16 E71 N101 G142 G143 G144 T145 G146 Y224 G10 Q11 A12 Q15 I16 E71 N101 G142 G143 G144 T145 G146 Y224
Gene Ontology
Molecular Function
GO:0003674 molecular_function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0007017 microtubule-based process
GO:0030317 flagellated sperm motility
GO:0036098 male germ-line stem cell population maintenance
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005929 cilium
GO:0031514 motile cilium
GO:0036064 ciliary basal body
GO:0036126 sperm flagellum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i7o, PDBe:8i7o, PDBj:8i7o
PDBsum8i7o
PubMed37989994
UniProtP05214|TBA3_MOUSE Tubulin alpha-3 chain (Gene Name=Tuba3a)

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