Structure of PDB 8ir3 Chain T

Receptor sequence
>8ir3T (length=266) Species: 9606 (Homo sapiens) [Search protein sequence]
TKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALKKPYGV
LYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDY
HVLDMIELGIENFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKS
LLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKSGRTPRI
ELEEMGPSLDLVLRRTHLASDDLYKLSMKMPKNISHDTFGTTYGRIHMQK
QDLSKLQTRKMKGLKK
3D structure
PDB8ir3 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
ChainT
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna T R14 A15 R17 F18 N27 Y63 K65 F80 K84 N253 H267 M268 K270 K282 R3 A4 R6 F7 N16 Y52 K54 F69 K73 N233 H247 M248 K250 K262
BS02 rna T K50 K57 N96 K97 K98 K39 K46 N85 K86 K87
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 maturation of LSU-rRNA
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ir3, PDBe:8ir3, PDBj:8ir3
PDBsum8ir3
PubMed37491604
UniProtQ9H7B2|RPF2_HUMAN Ribosome production factor 2 homolog (Gene Name=RPF2)

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