Structure of PDB 8ir1 Chain T

Receptor sequence
>8ir1T (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
TKRAKRFLEKREPKLNENIKNAMLIKGGNANATVTKVLKDVYALKKPYGV
LYKKKNITRPFEDQTSLEFFSKKSDCSLFMFGSHNKKRPNNLVIGRMYDY
HVLDMIELGIENFVSLKDIKNSKCPEGTKPMLIFAGDDFDVTEDYRRLKS
LLIDFFRGPTVSNIRLAGLEYVLHFTALNGKIYFRSYKLLLKKRTPRIEL
EEMGPSLDLVLRRTHLASDDLYKLSMKMPKNISHDTFGTTYGRIHMQKQD
LSKLQ
3D structure
PDB8ir1 Visualizing the nucleoplasmic maturation of human pre-60S ribosomal particles.
ChainT
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna T K13 R14 A15 R17 F18 N27 Y63 K64 K65 S77 F80 F81 K84 K252 L276 Q277 K2 R3 A4 R6 F7 N16 Y52 K53 K54 S66 F69 F70 K73 K230 L254 Q255
BS02 rna T K50 K57 N96 K97 K98 K39 K46 N85 K86 K87
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008097 5S rRNA binding
GO:0019843 rRNA binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470 maturation of LSU-rRNA
GO:0006364 rRNA processing
GO:0042254 ribosome biogenesis
GO:0042273 ribosomal large subunit biogenesis
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1902570 protein localization to nucleolus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ir1, PDBe:8ir1, PDBj:8ir1
PDBsum8ir1
PubMed37491604
UniProtQ9H7B2|RPF2_HUMAN Ribosome production factor 2 homolog (Gene Name=RPF2)

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