Structure of PDB 8a98 Chain T

Receptor sequence

>8a98T (length=153) Species: 347515 (Leishmania major strain Friedlin)

HYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQVL
AKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEANA
IEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMSE
KKE

3D structure

• PDB: 8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
• Chain: T
• Resolution: 2.46 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	T	H3 Y4 R23 H25 K27 F30 R42 Q46 R49 Q50 R62 Y63 G65 K66 R82 R85 M92 N97 N101 Q118 D120 R124 R127 T129 R131 A132 H133 G134 Y139	H1 Y2 R21 H23 K25 F28 R40 Q44 R47 Q48 R60 Y61 G63 K64 R80 R83 M90 N95 N99 Q116 D118 R122 R125 T127 R129 A130 H131 G132 Y137
BS02	rna	T	H25 K66 G68 R69 K80 R82 W83 P84 R85 K86 R127 Y130 G134 I136 T137 P138 Y139 M140	H23 K64 G66 R67 K78 R80 W81 P82 R83 K84 R125 Y128 G132 I134 T135 P136 Y137 M138
BS03	rna	T	Q9 S12	Q7 S10
BS04	rna	T	S5 K61 R62	S3 K59 R60
BS05	rna	T	R69 A71 Q72 K74	R67 A69 Q70 K72

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8a98, PDBe:8a98, PDBj:8a98
• PDBsum: 8a98
• PubMed: 38722744
• UniProt: Q4QAX6