Structure of PDB 8a3w Chain T

Receptor sequence

>8a3wT (length=152) Species: 347515 (Leishmania major strain Friedlin)

THYSRKPQVSSKSAKAKVSDLRCHYKNTFETANVINGMPLRKAQQLYRQV
LAKTRCIPFKRYNGKIGRTAQAKEWGQTKGRWPRKSVVAMMSLLKNAEAN
AIEKGLDPNQMVIKHVQVDQAARMRRRTYRAHGRITPYMCSPCHVQLFMS
EK

3D structure

• PDB: 8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
• Chain: T
• Resolution: 2.89 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	T	H25 K66 G68 R69 K80 R82 W83 R85 K86 Y130 G134 I136 T137 P138 Y139 M140	H24 K65 G67 R68 K79 R81 W82 R84 K85 Y129 G133 I135 T136 P137 Y138 M139
BS02	rna	T	H3 S5	H2 S4
BS03	rna	T	R69 A71 Q72 K74	R68 A70 Q71 K73
BS04	rna	T	T2 H3 R23 H25 K27 F30 R42 Q46 R49 Q50 L52 A53 R62 G65 R82 R85 M92 N97 N101 Q118 R124 R127 T129 R131 A132 H133 Y139	T1 H2 R22 H24 K26 F29 R41 Q45 R48 Q49 L51 A52 R61 G64 R81 R84 M91 N96 N100 Q117 R123 R126 T128 R130 A131 H132 Y138

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0015934 large ribosomal subunit
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
• PDBsum: 8a3w
• UniProt: Q4QAX6