Structure of PDB 7rmc Chain T

Receptor sequence
>7rmcT (length=561) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MKYVVVSGGVISGIGKGVLASSTGMLMKTLGLKVTSIKIDPYMNIDAGTM
SPLEHGECFVLDDGGETDLDLGNYERYLGVTLTKDHNITTGKIYSHVIAK
ERKGDYLGKTVQIVPHLTNAIQDWIERVAKIPVDDTGMEPDVCIIELGGT
VGDIESAPFVEALRQFQFKVGKENFALIHVSLVPVIHGEQKTKPTQAAIK
GLRSLGLVPDMIACRCSETLDKPTIDKIAMFCHVGPEQVVNVHDVNSTYH
VPLLLLEQKMIDYLHARLKLDEISLTEEEKQRGLELLSKWKATTGNFDES
METVKIALVGKYTNLKDSYLSVIKALEHSSMKCRRKLDIKWVEATDLEPE
AQESNKTKFHEAWNMVSTADGILIPGGFGVRGTEGMVLAARWARENHIPF
LGVCLGLQIATIEFTRSVLGRKDSHSAEFYPDIDEKNHVVVFMMRLGLRP
TFFQNETEWSQIKKLYGDVSEVHERHRHRYEINPKMVDELENNGLIFVGK
DDTGKRCEILELKNHPYYIATQYHPEYTSKVLDPSKPFLGLVAASAGILQ
DVIEGKYDLEA
3D structure
PDB7rmc Cryo-EM structures of CTP synthase filaments reveal mechanism of pH-sensitive assembly during budding yeast starvation.
ChainT
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTP T Q112 V114 Q112 V114
BS02 CTP T D153 I154 E155 D153 I154 E155
BS03 CTP T G13 G15 K16 G17 N73 Y77 L320 K324 G13 G15 K16 G17 N73 Y77 L320 K324
BS04 CTP T K191 T192 K193 K227 K191 T192 K193 K227
Gene Ontology
Molecular Function
GO:0003883 CTP synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0008654 phospholipid biosynthetic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
Cellular Component
GO:0000324 fungal-type vacuole
GO:0005737 cytoplasm
GO:0097268 cytoophidium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7rmc, PDBe:7rmc, PDBj:7rmc
PDBsum7rmc
PubMed34734801
UniProtP28274|URA7_YEAST CTP synthase 1 (Gene Name=URA7)

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