Structure of PDB 7mdz Chain T

Receptor sequence

>7mdzT (length=157) Species: 9986 (Oryctolagus cuniculus)

TNTKGKRRGTRYMFSRPFRKHGVVPLATYMRIYKKGDIVDIKGMGTVQKG
MPHKCYHGKTGRVYNVTQHAVGIVVNKQVKGKILAKRINVRIEHIKHSKS
RDSFLKRVKENDQKKKEAKEKGTWVQLKRQPAPPREAHFVRTNGKEPELL
EPIPYEF

3D structure

• PDB: 7mdz Discovery of C13-Aminobenzoyl Cycloheximide Derivatives that Potently Inhibit Translation Elongation.
• Chain: T
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	T	T2 N3 T4 K5 G6 K7 R8 R9 R12 Y13 M14 S16 R17 F19 H22 G23 D41 G46 T47 Q49 K50 G51 H54 Y57 H58 G59 K60 T61 T68 Q69 H70 A71 N77 K78 V80 L85 K87 R88 R92 K97 S101 S104 F105 R108 V109 N112 K116 W125 V126 L128 K129 R130 P132 F140 R142	T1 N2 T3 K4 G5 K6 R7 R8 R11 Y12 M13 S15 R16 F18 H21 G22 D40 G45 T46 Q48 K49 G50 H53 Y56 H57 G58 K59 T60 T67 Q68 H69 A70 N76 K77 V79 L84 K86 R87 R91 K96 S100 S103 F104 R107 V108 N111 K115 W124 V125 L127 K128 R129 P131 F139 R141
BS02	rna	T	R20 P26 A28	R19 P25 A27

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7mdz, PDBe:7mdz, PDBj:7mdz
• PDBsum: 7mdz
• PubMed: 34403584
• UniProt: G1SHQ2|RL21_RABIT Large ribosomal subunit protein eL21 (Gene Name=RPL21)