Structure of PDB 6vvv Chain T

Receptor sequence
>6vvvT (length=53) Species: 246196 (Mycolicibacterium smegmatis MC2 155) [Search protein sequence]
IDDLDLTVRSYNCLKREGVHTVGELVARTESDLLDIRNFGQKSIDEVKIK
LHQ
3D structure
PDB6vvv The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
ChainT
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna T V258 R259 V8 R9
BS02 dna T R259 N288 G290 Q291 K292 R9 N38 G40 Q41 K42
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:6vvv, PDBe:6vvv, PDBj:6vvv
PDBsum6vvv
PubMed33199626
UniProtA0QSL8|RPOA_MYCS2 DNA-directed RNA polymerase subunit alpha (Gene Name=rpoA)

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