Structure of PDB 5zwn Chain T

Receptor sequence
>5zwnT (length=539) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
DKYTALIHDENFSTLTLNVSRYPKSLAYWEKLLNYIVKASAPICKSTEPQ
LLKLIRCTYSSMLNEFPYLENYYIDFALLEYKLGNVSMSHKIFQRGLQAF
NQRSLLLWTSYLKFCNNVISHQKQLFKKYETAEEYVGLHFFSGEFWDLYL
EQISSRCTSSKKYWNVLRKILEIPLHSFSKFYALWLQRIDDIMDLKQLSQ
LTSKDELLKKLKIDINYSGRKGPYLQDAKKKLKKITKEMYMVVQYQVLEI
YSIFESKIYINYYTSPETLVSSDEIETWIKYLDYTITLQTDSLTHLNFQR
ALLPLAHYDLVWIKYSKWLINSKNDLLGAKNVLLMGLKFSLKKTEIIKLL
YSVICKLNEYVLLRNLLEKIESSYSDNVENVDDFEIFWDYLQFKTFCQNS
LYSSRYSDSQSNGLLNKELFDKVWKRLSCKEKKSGQEILLNNLVQFYSKD
TVEFVEKNIFQKIIEFGWEYYLQNGMFWNCYCRLIYFDTSRSYLDKRQYI
VRKIWPQIDKKFAQSVLPSLTEFCESYFPEEMDTLEEMF
3D structure
PDB5zwn Structures of the fully assembledSaccharomyces cerevisiaespliceosome before activation
ChainT
Resolution3.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna T S88 H91 H122 Q123 Q125 R157 C158 M194 D195 R221 K222 G223 S87 H90 H121 Q122 Q124 R156 C157 M193 D194 R220 K221 G222
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0030627 pre-mRNA 5'-splice site binding
Biological Process
GO:0000395 mRNA 5'-splice site recognition
GO:0000398 mRNA splicing, via spliceosome
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0000243 commitment complex
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005685 U1 snRNP
GO:0071004 U2-type prespliceosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5zwn, PDBe:5zwn, PDBj:5zwn
PDBsum5zwn
PubMed29794219
UniProtQ03776|PRP42_YEAST U1 small nuclear ribonucleoprotein component PRP42 (Gene Name=PRP42)

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