Structure of PDB 3p71 Chain T

Receptor sequence
>3p71T (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
DENDEGVRGTCEDASLCKRFAVSIGYWHDPYIQHFVRLSKERKAPEINRG
YFARVHGVSQLIKAFLRKTECHCQIVNLGAGMDTTFWRLKDEDLLSSKYF
EVDFPMIVTRKLHSIKCKPPLSSPILELHSEDTLQMDGHILDSKRYAVIG
ADLRDLSELEEKLKKCNMNTQLPTLLIAECVLVYMTPEQSANLLKWAANS
FERAMFINYEQVNMGDRFGQIMIENLRRRQCDLAGVETCKSLESQKERLL
SNGWETASAVDMMELYNRLPRAEVSRIESLEFLDEMELLEQLMRHYCLCW
ATKGGNELGLKEITY
3D structure
PDB3p71 The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1.
ChainT
Resolution2.7 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.233: [phosphatase 2A protein]-leucine-carboxy methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AN6 T T29 C30 K37 R73 G98 A99 D122 F123 D171 L172 R173 E198 C199 T10 C11 K18 R54 G79 A80 D103 F104 D152 L153 R154 E179 C180
Gene Ontology
Molecular Function
GO:0003880 protein C-terminal carboxyl O-methyltransferase activity
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008276 protein methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0018423 protein C-terminal leucine carboxyl O-methyltransferase activity
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006479 protein methylation
GO:0006481 C-terminal protein methylation
GO:0010906 regulation of glucose metabolic process
GO:0031333 negative regulation of protein-containing complex assembly
GO:0032259 methylation
GO:0036211 protein modification process
GO:0042981 regulation of apoptotic process
GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3p71, PDBe:3p71, PDBj:3p71
PDBsum3p71
PubMed21292165
UniProtQ9UIC8|LCMT1_HUMAN Leucine carboxyl methyltransferase 1 (Gene Name=LCMT1)

[Back to BioLiP]